Presentation of the current principles and methods for studying the metabolic transformation and disposition of xenobiotics, detailed examination of the chemistry of oxidation, reduction, hydrolysis and conjugation reaction from a mechanistic and empirical viewpoint and the importance of these reactions in the generation and removal of toxic intermediates. The role of structure, bonding, molecular configuration and physicochemical factors in the enzymatic reaction is assessed. Interaction of intermediates and metabolites with cellular macromolecules and possible toxic manifestations will be discussed. (Lecture 3 hours).
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